Chinese Journal of Catalysis ›› 2008, Vol. 29 ›› Issue (3): 209-211.

• Articles • Previous Articles     Next Articles

Suzuki Reactions of Aryl Bromides Catalyzed by Hydroxyapatite-Supported Manganese

QIAO Jiangbin1, ZHU Wenfang1, ZHUO Guanglan1*, ZHOU Hao2, JIANG Xuanzhen2   

  1. 1 Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang, China; 2 Department of Chemistry, Zhejiang University, Hangzhou 310014, Zhejiang, China
  • Received:2008-03-25 Online:2008-03-25 Published:2012-03-01

Abstract: Suzuki cross-coupling reactions between aryl bromides and phenylboronic acids were studied over a hydroxyapatite-supported Mn catalyst (MnHAP) for the first time. An increased yield was obtained over the fluoride ion-exchanged hydroxyapatite-supported Mn catalyst (MnFAP). Under optimized conditions, the yield was about 70%. The effect of solvent compositions and different substituents were studied over the MnFAP catalyst. The DMF-H2O mixture with a DMF/H2O volume ratio of 1/3 was the best solvent. Moderate yields (18%-46%) were obtained for all tested aryl bromides and phenylboronic acids substituted by different groups.

Key words: Suzuki reaction, hydroxyapatite, fluoride exchange, manganese, aryl bromide, phenylboronic acid