Addition of Diethylzinc to Aromatic Aldehydes Catalyzed by Hydrolase

Chinese Journal of Catalysis ›› 2009, Vol. 30 ›› Issue (5): 396-400.

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Addition of Diethylzinc to Aromatic Aldehydes Catalyzed by Hydrolase

WEI Xiaofei1, ZHENG Qingchuan2, JI Tengfei3, ZHAO Bo1, LI Chunyuan1, WANG Ping1, CAO Shugui1, WANG Zhi1, #, WANG Lei1, *

1Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, Jilin University, Changchun 130023, Jilin, China 2State Key Laboratory of Theoretical and Computational Chemistry, Jilin University, Changchun 130023, Jilin, China 3Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China

Online:2009-05-25 Published:2013-02-05

Abstract

Abstract: A novel application of hydrolase as catalyst for the addition of diethylzinc to aromatic aldehydes is reported, and a possible mechanism is proposed based on experimental observations and molecular dynamics simulation. The present observations extend the phenomenon of enzyme promiscuity.

Key words: hydrolase, diethylzinc, aromatic aldehyde, addition, enzyme, promiscuity

WEI Xiaofei;ZHENG Qingchuan;JI Tengfei;ZHAO Bo;LI Chunyuan;WANG Ping;CAO Shugui;WANG Zhi;#;WANG Lei;*. Addition of Diethylzinc to Aromatic Aldehydes Catalyzed by Hydrolase[J]. Chinese Journal of Catalysis, 2009, 30(5): 396-400.

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Addition of Diethylzinc to Aromatic Aldehydes Catalyzed by Hydrolase

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