Chinese Journal of Catalysis ›› 2010, Vol. 31 ›› Issue (5): 514-517.

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Synthesis of Chiral Bulky Monophosphite Ligands and Their Application in Cu-Catalyzed Asymmetric Conjugate Addition of Diethylzinc to Cyclic Enones

WAN Bo1,2, ZHAO Qinglu1,2, WANG Lailai1,*   

  1. 1State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China;2Graduate University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2010-05-25 Online:2010-05-25 Published:2013-12-05

Abstract: A series of new bulky monophosphite ligands derived from BINOL and adamantanecarbonyl chloride were employed in Cu-catalyzed enantioselective 1,4-conjugate addition of diethylzinc to cyclic enones (up to 61% ee).

Key words: asymmetric 1, 4-conjugate addition, bulky monophosphite, 2-cyclohexenone, diethylzinc, enantioselectivity