Kinetic Resolution of (RS)-4-Hydroxy-3-methyl-2-(2′-propynyl)-2-cyclopente-none Acetate by Lipase-Catalyzed Alcoholysis in Organic Media

Abstract

Abstract: (RS)-4-hydroxy-3-methyl-2-(2′-propynyl)-2-cyclopentenone acetate was successfully resolved by lipase-catalyzed alcoholysis through adjusting the basicity of the organic reaction system, and the product was obtained with both high conversion and ee value.

Key words: lipase, (RS)-4-hydroxy-3-methyl-2-(2&prime, -propynyl)-2-cyclopentenone, (RS)-4-hydroxy-3-methyl-2-(2&prime, -propynyl)-2-cyclopentenone acetate, alcoholysis, basic additive

CHENG Yongmei;WU Jianping;XU Gang;YANG Lirong*. Kinetic Resolution of (RS)-4-Hydroxy-3-methyl-2-(2′-propynyl)-2-cyclopente-none Acetate by Lipase-Catalyzed Alcoholysis in Organic Media[J]. Chinese Journal of Catalysis, 2010, 31(2): 225-228.

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Kinetic Resolution of (RS)-4-Hydroxy-3-methyl-2-(2′-propynyl)-2-cyclopente-none Acetate by Lipase-Catalyzed Alcoholysis in Organic Media

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