Substrate-promoted copper-catalyzed N-arylation of amino alcohols with aryl iodides in water

doi:10.1016/S1872-2067(12)60623-8

Abstract

Abstract:

An efficient method has been developed for the N-arylation of a variety of water-soluble amino alcohols (1.2 mmol) with aryl iodides (1.0 mmol) in water under CuI-catalyzed conditions. The reaction was conducted via substrate-promoted action and did not require an additional ligand or phase-transfer catalyst, and afforded the desired N-aryl amines in acceptable to excellent yields (64%-93%) under mild reaction conditions with a small excess of the amino alcohol.

Key words: Amino alcohol, Aqueous phase, Copper catalyst, N-Arylation reaction, Substrate promotion

Ming Jin, Dan Zhao, Guozhen He, Yao Tong, Shiqing Han. Substrate-promoted copper-catalyzed N-arylation of amino alcohols with aryl iodides in water[J]. Chinese Journal of Catalysis, 2013, 34(9): 1651-1655.

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URL: https://www.cjcatal.com/EN/10.1016/S1872-2067(12)60623-8

https://www.cjcatal.com/EN/Y2013/V34/I9/1651

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