催化学报

催化学报 ›› 2008, Vol. 29 ›› Issue (9): 878-880.

• 研究快讯 • 上一篇    下一篇

催化还原胺类衍生物N-单烷基化反应一锅法合成4,6-二(异丙基氨基)-1,3-苯二酚

金中豪,李到,马瑞,彭旭涛,王幸宜,卢冠忠   

  1. 华东理工大学工业催化研究所结构可控先进功能材料及其制备教育部重点实验室, 上海 200237
  • 收稿日期:2008-09-25 出版日期:2008-09-25 发布日期:2012-07-19

One-Pot Method to Synthesize 4,6-Bis(isopropylamino)benzene-1,3-diol by Catalytic Reductive Mono-N-alkylation of Amine Derivatives

JIN Zhonghao, LI Dao, MA Rui, PENG Xutao, WANG Xingyi*, LU Guanzhong   

  1. Laboratory for Advanced Materials, Research Institute of Industrial Catalysis, East China University of Science and Technology, Shanghai 200237, China
  • Received:2008-09-25 Online:2008-09-25 Published:2012-07-19

PDF

1226

被引次数

9

摘要： 以2-氯-4,6-二硝基-1,3-苯二酚为原料,丙酮为烷基源,氢气为还原剂,研究了在10%Pd/C催化剂上一锅法合成N-单烷基氨基苯酚化合物4,6-二(异丙基氨基)-1,3-苯二酚的反应工艺. 考察了反应条件如醋酸量、丙酮浓度、氢气压力、催化剂量和反应时间对反应的影响,开发出一条高收率、高选择性制备N-单烷基氨基苯酚化合物的合成路线.

关键词: 一锅法还原N-单烷基化反应, 加氢脱氯反应, 2-氯-4, 6-二硝基-1, 3-苯二酚, 4, 6-二(异丙基氨基)-1, 3-苯二酚

Abstract: An alternative method was studied for catalytically reductive hydrodechlorinatio n and mono-N-alkylation of 2-chloro-4,6-dinitrobenzene-1,3-diol, an i nexpensive material, to synthesize corresponding N-alkyl secondary aminophe nol, 4,6-bis(isopropylamino)benzene-1,3-diol, at a high yield by using aceton e as the alkyl source and hydrogen as the reducing reagent over 10%Pd/C catalyst .

Key words: one-pot reductive mono-N-alkylation, hydrodechlorination, 2-chloro-4, 6-dinitrobenzene-1, 3-diol, 4, 6-bis(isopropylamino)benzene-1, 3-diol