催化学报

催化学报 ›› 2008, Vol. 29 ›› Issue (3): 209-211.

• 研究快讯 • 上一篇    下一篇

羟基磷灰石负载锰催化溴苯的Suzuki反应

乔江彬1,朱雯芳1,卓广澜1,周浩2,姜玄珍2   

  1. 1 浙江理工大学化学系, 浙江杭州 310018; 2 浙江大学化学系, 浙江杭州 310014
  • 收稿日期:2008-03-25 出版日期:2008-03-25 发布日期:2012-03-01

Suzuki Reactions of Aryl Bromides Catalyzed by Hydroxyapatite-Supported Manganese

QIAO Jiangbin1, ZHU Wenfang1, ZHUO Guanglan1*, ZHOU Hao2, JIANG Xuanzhen2   

  1. 1 Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang, China; 2 Department of Chemistry, Zhejiang University, Hangzhou 310014, Zhejiang, China
  • Received:2008-03-25 Online:2008-03-25 Published:2012-03-01

PDF

786

被引次数

23

摘要： 以羟基磷灰石(HAP)负载Mn作为催化剂(MnHAP)催化溴苯与苯硼酸的Suzuki交叉偶联反应. 以氟离子交换羟基磷灰石的羟基(MnFAP)后,催化剂的活性显著提高,在优化的反应条件下能得到约70%的产率. 进一步考察了溶剂和不同取代基的影响. 结果表明, MnFAP作用下溶剂极性对反应有很大影响,当溶剂DMF/H2O比例为1/3时产率最高. 对于不同取代基取代的溴代芳烃或苯硼酸,可以得到中等产率(18%～46%)的偶联产物.

关键词: Suzuki 反应, 羟基磷灰石, 氟交换, 锰, 溴代芳烃, 苯硼酸

Abstract: Suzuki cross-coupling reactions between aryl bromides and phenylboronic acids were studied over a hydroxyapatite-supported Mn catalyst (MnHAP) for the first time. An increased yield was obtained over the fluoride ion-exchanged hydroxyapatite-supported Mn catalyst (MnFAP). Under optimized conditions, the yield was about 70%. The effect of solvent compositions and different substituents were studied over the MnFAP catalyst. The DMF-H2O mixture with a DMF/H2O volume ratio of 1/3 was the best solvent. Moderate yields (18%-46%) were obtained for all tested aryl bromides and phenylboronic acids substituted by different groups.

Key words: Suzuki reaction, hydroxyapatite, fluoride exchange, manganese, aryl bromide, phenylboronic acid