催化学报

催化学报 ›› 2007, Vol. 28 ›› Issue (8): 673-675.

• 研究快讯 • 上一篇    下一篇

多相双功能催化剂上的不对称直接Aldol反应

钟琳1,肖建良1,2,李灿1   

  1. 1 中国科学院大连化学物理研究所催化基础国家重点实验室, 辽宁大连 116023; 2 利物浦大学化学系, 利物浦L69 7ZD, 英国
  • 收稿日期:2007-08-25 出版日期:2007-08-25 发布日期:2011-08-19

Direct Asymmetric Aldol Reactions on Heterogeneous Bifunctional Catalyst

ZHONG Lin1, XIAO Jianliang1,2, LI Can1*   

  1. 1 State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, Liaoning, China; 2 Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, UK
  • Received:2007-08-25 Online:2007-08-25 Published:2011-08-19

PDF

870

被引次数

10

摘要： 通过将手性胺和酸基团同时引入到二氧化硅表面制备得到了一种多相双功能催化剂. 该催化剂在不对称直接Aldol反应中表现出中等的催化活性和对映选择性(ee值最高可达60%以上). 催化剂中手性胺和酸基团的协同作用对反应的活性和手性诱导至关重要.

关键词: 不对称催化, Aldol反应, 双功能催化剂, 有机-无机材料

Abstract: A heterogeneous bifunctional catalyst was synthesized by incorporating chiral amine and acid groups into silica. This catalyst showed modest reactivity and enantioselectivity (up to 60%ee) for the direct asymmetric aldol reactions. It is suggested that the suitable incorporation between the amine and the acid groups in the bifunctional solid catalyst is crucial for the reactivity and the chiral induction of the reactions.

Key words: asymmetric catalysis, aldol reaction, bifunctional catalyst, inorganic-organic material