催化学报

催化学报 ›› 2007, Vol. 28 ›› Issue (10): 847-849.

• 研究快讯 • 上一篇    下一篇

铱催化3-羟甲基-2H-苯并吡喃类化合物的不对称氢化

刘启宾,周永贵   

  1. 中国科学院大连化学物理研究所, 辽宁大连 116023
  • 收稿日期:2007-10-25 出版日期:2007-10-25 发布日期:2011-10-28

Iridium-Catalyzed Asymmetric Hydrogenation of (2H-chromen-3-yl)methanols

LIU Qibin, ZHOU Yonggui*   

  1. Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, Liaoning, China
  • Received:2007-10-25 Online:2007-10-25 Published:2011-10-28

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1000

被引次数

3

摘要： 从(1R,2S)-环己烷吡啶醇出发,合成了具有不同轴手性的反式环己烷骨架铱络合物,并将其应用于3-羟甲基-2H-苯并吡喃的不对称氢化中. 结果表明,当以Ir-8为催化剂,二氯甲烷为溶剂,氢气压力5 MPa, 室温反应16 h时,可以取得极好的反应活性,产物最高对映选择性可达94%.

关键词: 3-羟甲基-2H-苯并吡喃, 不对称氢化, 铱催化剂

Abstract: Trans-cyclohexane-backbone iridium complexes with different axial chirality were synthesized from (1R,2S)-2-(pyridin-2-yl)cyclohexanol, and their application in asymmetric hydrogenation of (2H-chromen-3-yl)methanols was investigated. When the hydrogenation was carried out using 1% Ir-8 as the catalyst at a hydrogen pressure of5 MPain dichloromethane for16 hat room temperature, excellent activities and up to 94% ee were obtained.

Key words: (2H-chromen-3-yl)methanol, asymmetric hydrogenation, iridium catalyst