催化学报

催化学报 ›› 2010, Vol. 31 ›› Issue (2): 225-228.

• 研究论文 • 上一篇    下一篇

有机相中利用脂肪酶催化的醇解反应拆分炔丙醇酮乙酸酯

程咏梅, 吴坚平, 徐刚, 杨立荣   

  1. 浙江大学化学工程与生物工程系, 浙江杭州 310027
  • 收稿日期:2010-02-25 出版日期:2010-02-25 发布日期:2013-09-02

Kinetic Resolution of (RS)-4-Hydroxy-3-methyl-2-(2′-propynyl)-2-cyclopente-none Acetate by Lipase-Catalyzed Alcoholysis in Organic Media

CHENG Yongmei, WU Jianping, XU Gang, YANG Lirong*   

  1. Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, China
  • Received:2010-02-25 Online:2010-02-25 Published:2013-09-02

PDF

968

被引次数

8

摘要： 研究了有机相中脂肪酶催化的炔丙醇酮乙酸酯的立体选择性醇解反应, 考察了碱的种类、酰基受体和溶剂等对反应的影响. 结果表明, 以四氢呋喃为溶剂, CH3OH 为酰基受体, Lipase PLG 脂肪酶为催化剂, Na2CO3 为碱性添加剂, 高底物浓度下 40 oC 反应 96 h 后, 底物转化率和产物 ee 值分别达到 49.5% 和 99.5%. 碱的添加极大地提高了反应速度.

关键词: 脂肪酶, 炔丙醇酮, 炔丙醇酮乙酸酯, 醇解, 碱性添加剂

Abstract: (RS)-4-hydroxy-3-methyl-2-(2′-propynyl)-2-cyclopentenone acetate was successfully resolved by lipase-catalyzed alcoholysis through adjusting the basicity of the organic reaction system, and the product was obtained with both high conversion and ee value.

Key words: lipase, (RS)-4-hydroxy-3-methyl-2-(2&prime, -propynyl)-2-cyclopentenone, (RS)-4-hydroxy-3-methyl-2-(2&prime, -propynyl)-2-cyclopentenone acetate, alcoholysis, basic additive