催化学报 ›› 2014, Vol. 35 ›› Issue (3): 357-361.DOI: 10.1016/S1872-2067(12)60754-2

• 研究论文 • 上一篇    下一篇

纯水中有氧条件下Pd/C催化的无配体Suzuki反应

饶小峰, 刘春, 张义霞, 高占明, 金子林   

  1. 大连理工大学精细化工国家重点实验室, 辽宁大连116024
  • 收稿日期:2013-10-20 修回日期:2013-11-22 出版日期:2014-02-26 发布日期:2014-02-26
  • 通讯作者: 刘春
  • 基金资助:

    国家自然科学基金(21276043);教育部新世纪优秀人才支持计划(NCET-10-0283).

Pd/C-catalyzed ligand-free and aerobic Suzuki reaction in water

Xiaofeng Rao, Chun Liu, Yixia Zhang, Zhanming Gao, Zilin Jin   

  1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, Liaoning, China
  • Received:2013-10-20 Revised:2013-11-22 Online:2014-02-26 Published:2014-02-26
  • Supported by:

    This work was supported by the National Natural Science Foundation of China (21276043) and the Ministry of Education Program for New Century Excellent Talents in University (NCET-10-0283).

摘要:

报道一种在纯水中Pd/C催化的高效Suzuki反应体系,该体系无需除氧,且无外加配体和添加剂,底物普适性广泛,含有亲水或疏水基团的溴代芳烃都能被高效活化. 此外,对部分杂环芳烃与芳基硼酸的偶联反应也有较好的催化效果. 该催化剂可高效循环使用三次,且性能无明显下降.

关键词: Suzuki反应, 钯, 碳, 无配体, 二异丙胺, 联芳化合物

Abstract:

A general and efficient catalytic system for Pd/C-catalyzed ligand-free aerobic Suzuki cross-coupling reactions was developed. The reaction tolerated a wide range of aryl bromides with a hydrophilic group or a hydrophobic group without any additives in water. Moreover, the catalytic system was successfully extended to the cross-couplings of heteroaryl halides with various arylboronic acids. The Pd/C catalyst could be reused three times without significant loss of catalytic activity.

Key words: Suzuki reaction, Palladium, Carbon, Ligand-free, Diisopropylamine, Biaryl