通过η3-苄基钯中间体零价钯催化的吲哚苄基化反应

doi:10.1016/S1872-2067(14)60191-1

催化学报 ›› 2015, Vol. 36 ›› Issue (1): 15-18.DOI: 10.1016/S1872-2067(14)60191-1

通过η³-苄基钯中间体零价钯催化的吲哚苄基化反应

赵正乐^a,b, 顾庆^b, 伍新燕^a, 游书力^a,b

a 华东理工大学结构可控先进功能材料及其制备教育部重点实验室和精细化工研究所, 上海200237;
b 中国科学院上海有机化学研究所金属有机国家重点实验室, 上海200032

收稿日期:2014-06-13 修回日期:2014-07-03 出版日期:2014-12-31 发布日期:2014-12-31
通讯作者: 伍新燕, 游书力
基金资助:
国家重点基础研究发展计划(973计划, 2010CB833300); 国家自然科学基金(21025209, 21121062, 21272253, 21332009).

Pd(0)-catalyzed benzylation of indole through η³-benzyl palladium intermediate

Zheng-Le Zhao^a,b, Qing Gu^b, Xin-Yan Wu^a, Shu-Li You^a,b

a Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China;
b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Received:2014-06-13 Revised:2014-07-03 Online:2014-12-31 Published:2014-12-31
Supported by:
This work was supported by the National Basic Research Program of China (973 Program, 2010CB833300) and the National Natural Science Foundation of China (21025209, 21121062, 21272253, 21332009).

摘要/Abstract

摘要：

本文报道了零价钯催化的吲哚苄基化反应, 获得了优秀的区域选择性. 使用Pd(PPh₃)₄作为催化剂, 在温和反应条件下, 以90%-99%的收率获得含有各类取代吲哚片段的三芳基甲烷化合物.

关键词: 苄基化, 吲哚, 三芳基甲烷, η³-苄基钯中间体

Abstract:

An efficient method has been developed for the Pd(0)-catalyzed benzylation of indoles, which occurred with exclusive regioselectivity. When this reaction was performed in the presence of Pd(PPh₃)₄, it provided access to a broad range of substituted indoles bearing diarylmethanes at their 3-position in 90%-99% yields under mild conditions.

Key words: Benzylation, Indole, Triarylmethane, η³-Benzyl palladium intermediate

赵正乐, 顾庆, 伍新燕, 游书力. 通过η³-苄基钯中间体零价钯催化的吲哚苄基化反应[J]. 催化学报, 2015, 36(1): 15-18.

Zheng-Le Zhao, Qing Gu, Xin-Yan Wu, Shu-Li You. Pd(0)-catalyzed benzylation of indole through η³-benzyl palladium intermediate[J]. Chinese Journal of Catalysis, 2015, 36(1): 15-18.

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通过η³-苄基钯中间体零价钯催化的吲哚苄基化反应

Pd(0)-catalyzed benzylation of indole through η³-benzyl palladium intermediate

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