催化学报 ›› 2015, Vol. 36 ›› Issue (1): 40-47.DOI: 10.1016/S1872-2067(14)60164-9

• 论文 • 上一篇    下一篇

钯催化烯丙基磺酰胺的分子内胺氟化反应

程家顺, 陈品红, 刘国生   

  1. 中国科学院上海有机化学研究所金属有机国家重点实验室, 上海200032
  • 收稿日期:2014-05-19 修回日期:2014-06-09 出版日期:2014-12-31 发布日期:2014-12-31
  • 通讯作者: 刘国生
  • 基金资助:

    国家重点基础研究发展计划(973计划, 2011CB808700); 国家自然科学基金(21225210, 20923005和21121062); 上海市科学技术委员会(11JC1415000); 中国科学院、国家外国专家局创新团队国际合作伙伴计划.

Pd-catalyzed intramolecular aminofluorination of allylic sulfamides

Jiashun Cheng, Pinhong Chen, Guosheng Liu   

  1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
  • Received:2014-05-19 Revised:2014-06-09 Online:2014-12-31 Published:2014-12-31
  • Supported by:

    This work was supported by the National Basic Research Program of China (973 program, 2011CB808700), the National Natural Science Foundation of China (21225210, 20923005 and 21121062), the Science and Technology Commission of Shanghai Municipality (11JC1415000), and the CAS/SAFEA International Partnership Program for Creative Research Teams.

摘要:

报道了钯催化的非活性烯烃的胺氟化反应, 在酸性添加剂HOAc的作用下, 反应以较好的收率和区域选择性地得到6-endo环合产物, 实现了氟代的环状磺胺类产物的有效合成.

关键词: 钯催化, 胺氟化, 烯烃, 氟代1,3-二胺, 6-endo环合

Abstract:

A facile Pd-catalyzed intramolecular aminofluorination reaction of allylic sulfamides was developed that can be used to prepare fluorinated 1,3-diamine derivatives. Acetic acid was essential for regulation to give the major 6-endo cyclization products.

Key words: Palladium-catalyzed, Aminofluorination, Alkene, Fluorinated 1,3-diamine, 6-Endo cyclization