催化学报 ›› 2015, Vol. 36 ›› Issue (1): 113-118.DOI: 10.1016/S1872-2067(14)60220-5

• 论文 • 上一篇    

一锅法绿色合成烯酰胺和1,3-二炔

梁浩, 任智卉, 王尧宇, 关正辉   

  1. 西北大学化学与材料科学学院, 合成与天然功能分子化学教育部重点实验室, 陕西西安710127
  • 收稿日期:2014-07-19 修回日期:2014-09-02 出版日期:2014-12-31 发布日期:2014-12-31
  • 通讯作者: 关正辉
  • 基金资助:

    国家自然科学基金(21272183); 陕西省科技厅“陕西省青年科技新星”基金(2012KJXX-26).

One-pot green synthesis of enamides and 1,3-diynes

Hao Liang, Zhihui Ren, Yaoyu Wang, Zhenghui Guan   

  1. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an 710127, Shaanxi, China
  • Received:2014-07-19 Revised:2014-09-02 Online:2014-12-31 Published:2014-12-31
  • Supported by:

    This work was supported by the National Natural Science Foundation of China (21272183) and the Fund of the Rising Stars of Shaanxi Province (2012KJXX-26).

摘要:

结合绿色化学概念, 将酮肟还原酰化和末端炔氧化偶联在一锅进行反应, 发展了一种Pd/Cu协同催化一锅绿色合成烯酰胺和1,3-二炔的新方法. 该方法无需外加任何氧化剂和还原剂, 可同时得到烯酰胺和1,3-二炔, 产率高, 反应条件温和.

关键词: 绿色合成, 酮肟, 末端炔, 烯酰胺, 1,3-二炔

Abstract:

A green organic synthetic method combining reductive acylation of ketoximes and oxidative coupling of terminal alkynes was developed. This novel process enables enamides and 1,3-diynes to be synthesized simultaneously in high yields and under mild conditions without the use of terminal reductants/oxidants.

Key words: Green synthesis, Ketoxime, Terminal alkyne, Enamide, 1,3-Diyne